Tumor Imaging with 99mTc-Labelled Antibody Fragmentst
نویسنده
چکیده
Althoughthe labelling of proteins with was established in 1964 by McAfee, et al., this isotope has been avoided by most investigators for the labelling of antibodies for tumor localization. There are several reasons for this: (1)the half-life is only 6 hours while most previous radiolabelled antibody localization studies have shown that the required tumor-toblood ratio needed for tumor visualization occurs after four days, i.e. after 16 half-lives; and
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